🔍 Description:

Not a peptide, NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in all living cells that plays a critical role in energy production, DNA repair, and cellular communication. It is essential for mitochondrial function and has significant anti-aging and metabolic benefits. NAD+ levels decline with age, and replenishing these levels has been shown to improve energy metabolism, support cognitive function, and promote longevity.

💪 Health Benefits:

– Energy Production: Boosts cellular energy by supporting mitochondrial function and enhancing ATP production, which is essential for all cellular processes.

– Anti-Aging: Delays aging by improving DNA repair mechanisms, reducing oxidative stress, and enhancing cellular resilience.

– Cognitive Function: Supports brain health and cognitive function by protecting neurons and improving neurotransmitter balance.

– Neurocognitive Health: Protects against cognitive impairment and neuroinflammation, preserves the mitochondria, and inhibits reactive oxygen species (ROS) via SIRT1 activation.

💉 Dosing/Administration:

– Typical Dosage: Varies based on the method of administration:

  – Intranasal Administration: Often used for neurocognitive support; a common protocol is 100 mg per dose administered daily, alternating nostrils.

  – Subcutaneous Injection: Doses can range up to 100 mg five days per week.

  – IV Infusion: Typically 500-1000 mg, used for more intensive therapeutic effects.

  – Oral Supplements: Generally range from 250-500 mg daily, though bioavailability is lower compared to other methods.

– Cycling: Usage varies based on individual health goals; often used in cycles or as part of a long-term health optimization strategy.

⚠️ Side Effects and Safety:

– Common Side Effects: Minimal; may include mild flushing, nausea, or headache, particularly with IV administration.

– Safety Profile: Safe for long-term use with proper dosing and monitoring. Intranasal administration is non-invasive and can be self-administered, making it a convenient option for ongoing use. IV administration should be performed by a healthcare professional.

🔬 Intranasal NAD+ Delivery:

– Benefits: Intranasal administration allows NAD+ to bypass the blood-brain barrier, delivering the molecule directly to the brain. This method is beneficial for cognitive health, with the potential to minimize side effects compared to other administration routes.

– Research Insights: Studies indicate that intranasal NAD+ can increase NAD+ content in the brain, potentially improving cognitive function and offering protection against neurodegenerative diseases.

📈 Research and Applications:

– Neurocognitive Disorders: NAD+ has been shown to improve cognitive function in patients with neurocognitive disorders or traumatic brain injury.

– Anti-Aging Research: Animal studies suggest that NAD+ supplementation can extend lifespan and mitigate premature aging diseases.

The Beyond Use Date (BUD) for reconstituted NAD+ varies depending on storage conditions:

    General BUD Guidelines: Once reconstituted, NAD+ should be stored in a refrigerator at temperatures between 36°F to 46°F (2°C to 8°C). Under these conditions, it typically has a BUD of 7 days

.

Freezing Option: If NAD+ is frozen, the BUD can be extended to 45 days

.

Multi-Dose Vial Consideration: Once a multi-dose vial is punctured, it should be discarded after 28 days, regardless of the initial BUD

.

These are instructions from a IV health clinic: ● Important Pre-Appointment Requirements for NAD: 

o Client request NAD+.   

▪ They should complete NAD intake form and consent by booking through 

the app 

▪ Reminder: pregnancy, breastfeeding mothers,  

● Certain cancer histories or genetic predispositions, and 

Cardiovascular risks are contraindicated, based on Medical 

Director determination 

o Once NAD intake form and consent are completed by client- they will schedule 

their patient consultation through the app 

o Once consult is complete the prescriber sends the prescription to the pharmacy 

for fulfillment.   

o NAD usually arrives to location – 

▪ Certain states require the prescription be sent to the patient themselves.  

▪ If not then, NAD will be shipped to the administering partner, under the 

patient’s name. This NAD is ONLY to be used for the patient whose name 

is on the label.  

● It is a felony to use/share a prescription on/with someone else.  

▪ Storage: Reminder you need to have safe storage for NAD, which is 

refrigerated once reconstituted. These vials have patient specific, PHI 

(protected health information), on them.  

● A locked refrigerator with a temperature log should be 

maintained  

o Any temperature excursion outside of labeled 

requirements should result in a call to the pharmacy who 

manufactured the product for next steps or disposal.   

▪ Follow up patient consults will be required for continuation of NAD every 

3 months

https://support.ivyrx.com/en/articles/8616463-when-should-i-discard-my-nad-vial

These findings suggest that NAD+ metabolism and its modulation hold significant therapeutic potential in the treatment of various diseases, including metabolic diseases, neurodegenerative disorders, aging-related conditions, and cancer. Further research and clinical trials are ongoing to explore the full therapeutic potential of NAD+ and its metabolites in the prevention and treatment of a wide range of diseases.

Dosing Protocols

The recommended dose for general health is to start out with 20mg NAD+ and, as desired, slowly ramp up to 100mg NAD+ 1-3 times per week.

Side Effects

The injection of NAD+ may cause adverse reactions and side effects, such as headache, shortness of breath, constipation, increased plasma bilirubin, and decreased levels of gamma-glutamyl transferase, lactate dehydrogenase, and aspartate aminotransferase.

Disclaimer

The information provided here is for informational purposes only and should not be considered as medical advice. Individuals should always consult with a qualified healthcare professional for personalized guidance and recommendations regarding the use of NAD+ supplements or any other medication.

Potential Risks

The potential risks associated with the long-term use of NAD+ supplementation are not extensively documented in the scientific literature. Further research is needed to establish a comprehensive understanding of the long-term safety profile and potential risks of prolonged NAD+ supplementation.

Journal Articles / Scientific Studies

“NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential” – Nature

https://www.nature.com/articles/s41392-020-00311-7

“Therapeutic application of natural products: NAD+ metabolism as potential target” – ScienceDirect

https://www.sciencedirect.com/science/article/pii/S0944711323001290

“NAD+ intermediates: The biology and therapeutic potential of NMN and NR” – PMC – NCBI

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842119/